Triterpenoids and Sterols from the Leaves and Twigs of Melia azedarach
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چکیده
منابع مشابه
Cytotoxic tirucallane triterpenoids from Melia azedarach fruits.
The phytochemical investigation of the dichloromethane-soluble part of the methanol extract obtained from the fruits of Melia azedarach afforded one new tirucallane-type triterpene, 3-alpha-tigloylmelianol and three known tirucallanes, melianone, 21-beta-acetoxy-melianone, and methyl kulonate. The structure of the isolated compounds was mainly determined by 1D and 2D NMR experiments as well as ...
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Bioassay guided purification of the ethyl acetate extract of leaves of Melia azedarach led to the isolation of the limonoid 1-cinnamoyl-3,11-dihydroxymeliacarpin, which showed IC50 values of 6 microM and 20 microM for vesicular stomatitis (VSV) and herpes simplex (HSV-1) viruses, respectively. Its structure was established by spectroscopic methods.
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Systematic fractionation of a fruit extract from Argentine Melia azedarach L., which was monitored by an insect antifeedant bioassay, led to the isolation of meliartenin, a limonoid antifeedant, which existed as a mixture of two interchangeable isomers. At 4 microg/cm2 and 1 microg/cm2, the isomeric mixture was as active as azadirachtin in strongly inhibiting the larval feeding of Epilachna pae...
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A new lanostan-type triterpenoid with hydroperoxy group, toosendanin A (1), together with two known triterpenoids, meliastatin 3 (2) and ursolic acid (3), were isolated and identified from the stems of Melia toosendan. The structures of these compounds were elucidated by 1Dand 2D-NMR spectra and other spectroscopic studies. These compounds were assayed for the antibacterial activities against s...
متن کاملAntitrypanosomal activity of triterpenoids and sterols from the leaves of Strychnos spinosa and related compounds.
Fractionation of an antitrypanosomal lipophilic leaf extract from Strychnos spinosa led to the isolation of eight triterpenoids and sterols in this plant part for the first time. Two of these were found to possess in vitro antitrypanosomal activity, namely, saringosterol (14) and 24-hydroperoxy-24-vinylcholesterol (15), with IC(50) values of 7.8 +/- 1.2 and 3.2 +/- 1.2 microM, respectively. The...
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ژورنال
عنوان ژورنال: Natural Products and Bioprospecting
سال: 2014
ISSN: 2192-2195,2192-2209
DOI: 10.1007/s13659-014-0019-1